In 1996, a project began at The University of Georgia College of Veterinary Medicine to create teaching aids to help visualize the difficult to understand disease of Equine Colic. After several presentations of the finished materials, it was clear that there was a deep interest within the equine community to have access to these materials for teaching purposes worldwide. With the help and guidance of the University of Georgia Research Foundation, the small group of inventors created a interactive interface in which their images could be viewed. This program became "The Glass Horse" CD and the Glass Horse Project was born.

Soon to follow, with additional help aiding the original group, the "Elements of the Equine Distal Limb" CD was created, providing veterinary students and practitioners with an interactive exploration of the equine distal limb. This interactive program went on to win the 2005 Dr. Frank Netter Award, an annual award presented by the Vesalius Trust for Special contributions to Medical Education.

As advancements were made in the understanding of equine colic and in the field of computer-generated imagery, a newer, more robust program was produced to replace the original "Glass Horse" CD called "The Equine Colic" CD. Besides more accurate and realistic anatomy, this CD contained much more information regarding diseased and normal anatomy alike.

The Glass Horse, LLC then merged into Science In 3D, Inc., a company with broader goals in mind that can expand beyond equine medicine and bring teaching aids to as many branches of science that it can reach.